Avoiding extinction: A Q&A with Gladstone AI’s Jeremie Harris

Midjourney

In November 2022, the US Department of State commissioned a comprehensive report on the risks of artificial intelligence. The government turned to Gladstone AI, a four-person firm founded the year before to write such reports and brief government officials on matters concerning AI safety.

Gladstone AI interviewed more than 200 people working in and around AI about what risks keep them up at night. Their report, titled “Defense in Depth: An Action Plan to Increase the Safety and Security of Advanced AI,” released to the public on March 11.

The short version? It’s pretty dire: “The recent explosion of progress in advanced artificial intelligence has brought great opportunities, but it is also creating entirely new categories of weapons of mass destruction-like and WMD-enabling catastrophic risks.” Next to the words “catastrophic risks” is a particularly worrying footnote: “By catastrophic risks, we mean risks of catastrophic events up to and including events that would lead to human extinction.”

With all that in mind, GZERO spoke to Jeremie Harris, co-founder and CEO of Gladstone AI, about how this report came to be and how we should rewire our thinking about the risks posed by AI.

This interview has been edited for clarity and length.

GZERO: What is Gladstone and how did the opportunity to write this report come about?

Jeremie Harris: After GPT-3 came out in 2020, we assessed that the key principle behind it might be extensible enough that we should expect a radical acceleration in AI capabilities. Our views were shaped by our technical expertise in AI (we'd founded a now-acquired AI company in 2016), and by our conversations with friends at the frontier labs, including OpenAI itself.

By then, it was already clear that a ChatGPT moment was coming, and that the US government needed to be brought up to speed. We briefed a wide range of stakeholders, from cabinet secretaries to working-level action officers on the new AI landscape. A year before ChatGPT was released, we happened upon a team at the State Department that recognized the importance of AI scaling up with larger, more powerful models. They decided to commission an assessment of that risk set a month before ChatGPT launched, and we were awarded the contract.

You interviewed 200 experts. How did you determine who to talk to and who to take most seriously?

Harris: We knew who the field's key contributors were, and had spoken to many of them personally.

Our approach was to identify and engage all of the key pockets of informed opinion on these issues, from leadership to AI risk skeptics, to concerned researchers. We spoke to members of the executive, policy, safety, and capabilities teams at top labs. In addition, we held on-site engagements with researchers at top academic institutions in the US and U.K., as well as with AI auditing companies and civil society groups.

We also knew that we needed to account for the unique perspective of the US government's national security community, which has a long history of dealing with new emerging technologies and WMD-like risks. We held unprecedented workshops that brought together representatives and WMD experts from across the US interagency to discuss AI and its national security risks, and had them red-team our recommendations and analysis.

What do you want the average person to know about what you found?

Harris: AI has already helped us make amazing breakthroughs in fields like materials science and medicine. The technology’s promise is real. Unfortunately, the same capabilities that create that promise also create risks, and although we can't be certain, a significant and growing body of data does suggest that these risks could lead to WMD-scale effects if they're not properly managed. The question isn't how do we stop AI development, but rather, how can we implement common-sense safeguards that AI researchers themselves are often calling for, so that we can reap the immense benefits.

Our readership is (hopefully) more informed than the average person about AI. What should they take away from the report?

Harris: Top AI labs are currently locked in a race on the path to human-level AI, or AGI. This competitive dynamic erodes the margins that they otherwise might be investing in developing and implementing safety measures, at a time when we lack the technical means to ensure that AGI-level systems can be controlled or prevented from being weaponized. Compounding this challenge is the geopolitics of AI development, as other countries develop their own domestic AI programs.

This problem can be solved. The action plan lays out a way to stabilize the racing dynamics playing out at the frontier of the field; strengthen the US government's ability to detect and respond to AI incidents; and scale AI development safely domestically and internationally.

We suggest leveraging existing authorities, identifying requirements for new legal regimes when appropriate, and highlighting new technical options for AI governance that make domestic and international safeguards much easier to implement.

What is the most surprising—or alarming—thing you encountered in putting this report together?

Harris: From speaking to frontier researchers, it was clear that labs are under significant pressure to accelerate their work and build more powerful systems, and this increasingly involves hiring staff who are more interested in pushing forward capabilities as opposed to addressing risks. This has created a significant opportunity: many frontier lab executives and staff want to take a more balanced approach. As a result, the government has a window to introduce common-sense safeguards that would be welcomed not only by the public, but by important elements within frontier labs themselves.

Have anything to make us feel good about where things are headed?

Harris: Absolutely. If we can solve for the risk side of the equation, AI offers enormous promise. And there really are solutions to these problems. They require bold action, but that's not unprecedented: we've had to deal with catastrophic national security risks before, from biotechnology to nuclear weapons.

AI is a different kind of challenge, but it also comes with technical levers that can make it easier to secure and assure. On-chip governance protocols offer new ways to verify adherence to international treaties, and fine-grained software-enabled safeguards can allow for highly targeted regulatory measures that place the smallest possible burden on industry.

More from GZERO Media

An armored vehicle of Nigerian Security Forces drives by newly built homes, ahead of the community re-opening ceremony which was destroyed by Boko Haram armed militants in 2015, in Ngarannam, Borno State, Nigeria, October 21, 2022.
REUTERS/Christophe Van Der Perre

There has been a rise in attacks in northeastern Nigeria by Boko Haram and a rival group called the Islamic State West Africa Province, spurring concerns that jihadists might be making a strong return in the region.

Canada’s Prime Minister Mark Carney speaks with members of the media as he walks into his office after the Liberal Party staged a major political comeback to retain power in parliamentary elections, in Ottawa, Ontario, Canada, on April 29, 2025.

REUTERS/Jennifer Gauthier

Prime Minister Mark Carney may have won the battle for power in Canada, but his country’s war of words with US President Donald Trump is only just beginning. And before that all begins, the Liberal leader must form a government.

U.S. President Donald Trump and Indian Prime Minister Narendra Modi shake hands as they attend a joint press conference at the White House in Washington, D.C., U.S., February 13, 2025.
REUTERS/Kevin Lamarque

If there’s a winner from President Donald Trump’s trade wars, India is a good candidate. Its longtime rivalry with China gives Prime Minister Narendra Modi ample motive to build new bridges with the United States.

Proud Source became a Walmart supplier in 2021. Today, its team has grown by 50%, and it's the largest employer in Mackay, ID. Walmart supports small businesses across the country, and nearly two-thirds of Walmart's product spend is on products made, grown, or assembled in America. It’s all a part of Walmart’s $350 billion investment in US manufacturing, which helps small businesses grow and supports US jobs. Learn more about Walmart’s commitment to US manufacturing.

Quantum technology offers the next frontier of innovation. As the global race for quantum technology intensifies, Microsoft Vice Chair and President Brad Smith highlights the need for the United States to harness its heritage of scientific innovation and outlines three strategic actions to ensure American quantum leadership. These actions include increasing government-funded quantum research, developing a skilled quantum workforce, and securing the quantum supply chain. Learn more here.