Israel tries to blow up US-Iran nuclear talks. What happens now?

Israel tries to blow up US-Iran nuclear talks. What happens now?
Annie Gugliotta

Iran has vowed to avenge Sunday's attack on its Natanz nuclear facility. Tehran blames Israel, which — as in the past — has neither confirmed nor denied it was responsible. And all this happens just days after indirect talks on US plans to rejoin the 2015 Iran nuclear deal resumed in Vienna. What the Iranians do now will determine the immediate future of those negotiations, a Biden administration priority.

What happened? Natanz, one of Iran's most important sites for uranium enrichment, was hit by an explosion that affected the power system that supplies the centrifuges. The damage will likely set back the country's efforts to enrich uranium to weapons-grade levels by some time. So far it's unclear whether it was a cyberattack similar to the Stuxnet malicious worm jointly developed by Israel and the US that destroyed one-fifth of Iran's centrifuges in 2010, or a bomb like the one that caused a July 2020 fire in the same facility.

Why now? The timing of the attack as US-Iran nuclear talks are ongoing is no coincidence. Israel fiercely opposed the original agreement championed six years ago by the Obama administration and was delighted when Donald Trump walked out of the deal in 2018 and later slapped crippling economic sanctions on Iran. To move talks forward, President Biden is willing to lift some of those sanctions, but Tehran, cautious about looking desperate so early in the discussions, has been playing hard to get.

The Israelis now worry that Iran has restarted enriching uranium at higher levels and that many of the deal's so-called "sunset clauses" expire in 2026, so Iran could begin to significantly expand its nuclear program while (technically) adhering to the terms of the agreement. Tel Aviv feels it's urgent to stop version 2.0 of the nuclear deal before Iran comes even close to getting the bomb.

How does it affect the US-Iran nuclear talks? It's too soon to ascertain whether the attack will diminish Iran's key bargaining chip: threatening to enrich uranium faster. What is virtually guaranteed, however, is that its aftermath will poison the domestic political environment in Iran, where any concession to "Great Satan" is always a hard sell, even more so now with a presidential election coming up in two months.

While the Americans' negotiating hand has strengthened, Natanz will further erode a mutual willingness to compromise — which is already very low after Iran stopped complying with the deal's terms on uranium enrichment in May 2019, and the high-profile assassination of a top Iranian general ordered by Trump in early 2020.

Who benefits? Clearly, Israel, for two reasons. First, whatever the full extent of the damage, it has physically undermined Iran's nuclear program, in the near term at least. Second, it has complicated a diplomatic process the Israelis would like to stop. Iran is now left to choose between a forceful retaliation that would delay any lifting of sanctions and an easing of economic hardship inside Iran, or a muted response that could make Iran's leaders appear weak just at the moment they'd like to be driving a hard bargain.

What happens next? The fallout from Natanz will put immense pressure on the Vienna talks, likely hardening Iran's position and reducing the odds of reaching an agreement before the presidential vote in June. Regardless of the election outcome, the decision on whether to rejoin the nuclear deal will be made by Supreme Leader Ali Khamenei.

Negotiations will continue. Iran's sanction-plagued economy suffered mightily last year due to the pandemic and low prices for the oil it's still able to export. Doing whatever it takes to get an agreement may not be popular for many conservatives at home, but US sanctions relief is too big an economic incentive for Iran to ignore.

In short, both the US and Iran still want to return to the original deal. That's why, unfortunately for Israel's government, the question is not if but when a new nuclear agreement will be signed.

More from GZERO Media

European Commission President Ursula von der Leyen delivers the State of the European Union address to the European Parliament, in Strasbourg, France, September 10, 2025.
REUTERS/Yves Herman

While the European Union has never been more critical, it is also facing a trifecta of divisive challenges.

In this episode of “Local to global: The power of small business,” host JJ Ramberg sits down with Chapin Flynn, Senior Vice President of Transit and Urban Mobility at Mastercard, and Mark Langmead, Director of Revenue & Compass Operations at TransLink in Vancouver, to explore how cities are making transit easier, faster, and more seamless for riders–an approach known as frictionless urban mobility.

United States President Donald J Trump awaits the arrival Saudi Crown Prince Mohammed bin Salman Al Saud at the White House in Washington, DC, USA, on November 18, 2025. Featuring: Donald J Trump Where: Washington, District of Columbia, United States When: 18 Nov 2025
Credit: Anna Rose Layden/POOL via CNP
A photo taken on September 14, 2024, shows seafood at Jimiya fishing port in Qingdao, China, on September 14, 2024. On September 20, 2024, China and Japan reach a consensus on the issue of the discharge of contaminated water from the Fukushima Daiichi nuclear power plant, and China states that it will gradually resume the import of Japanese aquatic products that meet the regulations.
(Photo by Costfoto/NurPhoto)