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An adult female Anopheles mosquito bites a human body to begin its blood meal at Tehatta, West Bengal; India on 24/02/2023.
Djibouti goes high-tech to take a bite out of malaria
The coastal country of Djibouti, one of the smallest by population in Africa, has a big problem in a tiny package: An invasive species of mosquito from the Indian subcontinent has driven malaria rates through the roof, so the government on Thursday released thousands of genetically modified bugs in a bid to save thousands of lives.
How deadly is the disease? Malaria has probably killed more human beings over the sweep of history than any other single infectious disease, and African governments have been fighting for decades to eliminate it. Djibouti darn near made it: In 2012, the country recorded just 27 cases.
But since then, an invasive species has arrived. Unlike the mosquitoes indigenous to most of Africa, the new bugs thrive in urban environments and bite during the day, making them impossible to avoid. In 2020, over 70,000 people contracted malaria — one in every 15 Djiboutians — of whom 190 died. The invasive bugs are spreading to important cities in Ethiopia and Kenya, and have been found as far away as Lagos, Nigeria, a metropolis of over 15 million.
Fight bugs with bugs: Working with scientists at US firm Oxitec, Djibouti released thousands of genetically modified versions of the invasive mosquitos whose female offspring die quickly. Since only females of the species bite humans, the hope is reducing their number will reduce human exposure.
Similar programs in Brazil met with astonishing success, driving down the population of dengue-carrying mosquitoes by 96%, a model later copied by Panama and the Cayman Islands. We’re watching Djibouti’s plan with great hope.
DNA Helix.
CRISPR gets an AI upgrade
CRISPR, the gene-editing method that won two female scientists the 2020 Nobel Prize in Chemistry, may soon get infused with artificial intelligence. One Northern California startup called Profluent is expected to present its new paper at a gene-editing conference next month, which describes its work using AI to analyze biological data and create new gene-editing systems.
As one professor explained to the New York Times, it’s a departure from how CRISPR typically does gene replacement. Instead of altering genes based on discoveries in nature, the startup instead uses novel methods surfaced by its AI. “They have never existed on Earth,” University of California, San Francisco professor James Fraser said. “The system has learned from nature to create them, but they are new.”
Gene-editing is rife with ethical quandaries, such as questions around modifying human embryos, which could be exacerbated by the rise of AI. Still, CRISPR provides hope: it could provide cures to countless diseases and is already providing innovative new treatments for sickle-cell anemia.
Profluent also chose to open-source one of its gene editors, OpenCRISPR-1, though the underlying AI will stay under wraps, the company said.