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Beijing's Tiananmen Square on June 4, 2025, the 36th anniversary of China's Tiananmen Square crackdown on pro-democracy demonstrators.
HARD NUMBERS: Tiananmen Square anniversary, Prison break in Pakistan, & More
36: Today marks the 36th anniversary of China’s deadly crackdown on pro-democracy protesters occupying Tiananmen Square on June 4th, 1989. The death toll from the day remains disputed, though certain groups have put it in the thousands. US Secretary of State Marco Rubio commemorated the crackdown yesterday, incurring the wrath of Beijing’s Foreign Ministry.
200: More than 200 inmates escaped a Pakistani prison in Karachi, a city of more than 20 million people, on Tuesday after a series of earthquakes damaged the facility. Early reports say police have re-arrested 80 of the inmates, meaning 120 or so remained at large.
4: “I want to see the tax cuts made permanent, but I also want to see the $5 trillion in new debt removed from the bill. At least4 of us in the Senate feel this way.” That’s the comment US Sen. Rand Paul (R-KY) made on X on Tuesday about President Donald Trump’s “Big Beautiful Bill.” If four Republican senators vote no on the bill, it will fail.
2: On Tuesday, two Chinese nationals were accused of smuggling a fungus into the United States that officials say is a potentially “dangerous biological pathogen.” The US Attorney’s Office in the eastern district of Michigan cites scientific reports that call this fungus a “potential agroterrorism weapon” that can destroy wheat, barley, maize and rice crops — and can sicken those who eat contaminated products.
How the Department of Homeland Security’s WMD office sees the AI threat
The US Department of Homeland Security is preparing for the worst possible outcomes from the rapid progression of artificial intelligence technology technology. What if powerful AI models are used to help foreign adversaries or terror groups build chemical, biological, radiological, or nuclear weapons?
The department’s Countering Weapons of Mass Destruction office, led by Assistant Secretary Mary Ellen Callahan, issued a report to President Joe Biden that was released to the public in June, with recommendations about how to rein in the worst threats from AI. Among other things, the report recommends building consensus across agencies, developing safe harbor measures to incentivize reporting vulnerabilities to the government without fear of prosecution, and developing new guidelines for handling sensitive scientific data.
We spoke to Callahan about the report, how concerned she actually is, and how her office is using AI to further its own goals while trying to outline the risks of the technology.
This interview has been edited for clarity and length.
GZERO: We profile a lot of AI tools – some benign, some very scary from a privacy or disinformation perspective. But when it comes to chemical, biological, radiological, and nuclear weapons, what do you see as the main threats?
Mary Ellen Callahan: AI is going to lower barriers to entry for all actors, including malign actors. The crux of this report is to look for ways to increase the promise of artificial intelligence, particularly with chemical and biological innovation, while limiting the perils, finding that kind of right balance between the containment of risk and fostering innovation.
We’re talking in one breath about chemical, biological, radiological, and nuclear threats — they’re all very different. Is there one that you’re most concerned about or see as most urgent?
I don’t want to give away too many secrets in terms of where the threats are. Although the task from the president was chemical, biological, radiological, nuclear threats, we focus primarily on chemical and biological threats for two reasons: One, chemical and biological innovation that is fostered by artificial intelligence is further along, and two, chemical and biological formulas and opportunities have already been included in some AI models.
And also because relatedly, the Department of Energy, which has a specialization in radiological and nuclear threats, is doing a separate classified report.
So, that’s less about the severity of the problem and more about what we’ll face soonest, right?
Well, anything that’s a WMD threat is low probability, but high impact. So we’re concerned about these at all times, but in terms of the AI implementation, the chemical and biological are more mature, I’d say.
How has the rise of AI changed the focus of your job? And is there anything about AI that keeps you up at night?
I would actually say that I am more sanguine now, having done a deeper dive into AI. One, we’re early in the stages of artificial intelligence development, and so we can catch this wave earlier. Two, there is a lot of interest and encouragement with regard to the model developers working with us proactively. There are chokepoints: The physical creation of these threats remains hard. How do you take it from ideation to execution? And there are a lot of steps between now and then.
And so what we’re trying to build into this guidance for AI model developers and others is pathway defeat — to try to develop off-ramps where we can defeat the adversaries, maybe early in their stage, maybe early as they are dealing with the ideation, [so they’re] not even able to get a new formula, or maybe at different stages of the development of a threat.
How are you thinking about the threat of open-source AI models that are published online for anyone to access?
We talked a little bit about open-source, but that wasn’t the focus of the report. But, I think that the more important thing to focus on is the sources of the ingestion of the data – as I mentioned, there is already public source data related to biology and to chemistry. And so whether or not it is an open-source model or not, it's the content of the models that I'm more focused on.
How do you feel about the pace of regulation in this country versus the pace of innovation?
We’re not looking at regulations to be a panacea here. What we’re trying to do right now is to make sure that everyone understands they have a stake in making artificial intelligence as safe as possible, and really to develop a culture of responsibility throughout this whole process — using a bunch of different levers. One lever is the voluntary commitments.
Another lever is the current laws. The current US regime between export controls, privacy, technology transfer, intellectual property, all of those can be levers and can be used in different ways. Obviously, we need to work with our international allies and make sure that we are working together on this. I don’t want to reveal too much, but there is interest that there can be some allied response in terms of establishing best practices.
Secretary Alejandro Mayorkas has noted that regulation can be backward-looking and reactive and might not keep up with the pace of technology. So, therefore, we’re not suggesting or asking for any new authorities or regulations in the first instance. But if we identify gaps, we may revisit whether new authorities or laws are needed.
In terms of legislation, do you think you have what you need to do your job? Or are there clear gaps in what’s on the books?
I actually think that the diverse nature of our laws is actually a benefit and we can really leverage and make a lot of progress with even what we have on the books now — export controls, technology transfers, intellectual property, criminal behavior, and obviously if we have CFATS on the books, that would be great — the Chemical Facility Anti-Terrorism Standards from my friends at CISA. But we do have a lot of robust levers that we can use now. And even those voluntary commitments with the model developers saying they want to do it — if they don’t comply with that, there could even be civil penalties related to that.
Can you tell me about the safe harbor measure that your report recommends and how you want that to work?
There are two aspects to the safe harbor. One is having an “if you see something, say something” aspect. So that means people in labs, people who are selling products, people who say stuff like, “that doesn’t ring true.” This standard can be used as a culture of responsibility.
And if somebody does report, then there could be a safe harbor reporting element — whether they’ve done something inadvertently to create a new novel threat, or they’ve noticed something in the pipeline. The safe harbor for abstaining from civil or criminal prosecution — that may need regulation.
Are you using AI at all in your office?
Yep. Actually, we are using AI on a couple of different detection platforms. The Countering Weapons of Mass Destruction Office has the subject matter expertise for CBRN threats here in the department and we provide training, technology, equipment, and detection capability. So we’ve been using algorithms and AI to help refine our algorithms with regard to identifying radiological, nuclear, chemical, and biological threats. And we’re going to continue to use that. We also are using AI as part of our biosurveillance program as well, both in trying to identify if there is a biodetection threat out there, but also if there is information that would indicate a biological threat out there in the country, and we’re trying to use AI to look for that in content.
Let’s end on an optimistic note. Is there anything else that gives you hope about AI factoring into your work?
The promise of AI is extraordinary. It really is going to be a watershed moment for us, and I'm really excited about this. I think thinking about the safety and security of the chemical and biological threats at this moment is exactly the right time. We’ve got to get in there early enough to establish these standards, these protocols, to share guidance, to fold in risk assessments into these calculations for the model developers, but also for the public at large. So I’m fairly bullish on this now.